Associations of hippocampal metabolism and regional brain grey matter in neuroleptic-naïve ultra-high-risk subjects and first-episode schizophrenia

I Nenadic; R Maitra; S Basu; M Dietzek; N Schönfeld; C Lorenz; A Gussew; GP Amminger; P McGorry; JR Reichenbach; H Sauer; C Gaser; S Smesny

Journal article

Associations of hippocampal metabolism and regional brain grey matter in neuroleptic-naïve ultra-high-risk subjects and first-episode schizophrenia

I Nenadic, R Maitra, S Basu, M Dietzek, N Schönfeld, C Lorenz, A Gussew, GP Amminger, P McGorry, JR Reichenbach, H Sauer, C Gaser, S Smesny

European Neuropsychopharmacology | ELSEVIER SCIENCE BV | Published : 2015

DOI: 10.1016/j.euroneuro.2015.05.005

Abstract

Hippocampal pathology has been shown to be central to the pathophysiology of schizophrenia and a putative risk marker for developing psychosis. We applied both 1H MRS (proton magnetic resonance spectroscopy) at 3Tesla and voxel-based morphometry (VBM) of high-resolution brain structural images in order to study the association of the metabolites glutamate (Glu) and N-acetyl-aspartate (NAA) in the hippocampus with whole-brain morphometry in 31 persons at ultra-high-risk for psychosis (UHR), 18 first-episode schizophrenia patients (Sz), and 42 healthy controls (all subjects being neuroleptic-naïve). Significantly diverging associations emerged for UHR subjects hippocampal glutamate showed posi..

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University of Melbourne Researchers

Paul Amminger Author

Patrick McGorry Author

Related Projects (1)

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Grants

Awarded by Friedrich-Schiller-Universität Jena

Funding Acknowledgements

This study was partially supported through Grants of German Research Foundation (Deutsche Forschungsgemeinschaft, DFG, Grant Sm 68/3-1, to St.S.). I.N. was supported by a Junior Scientist Grant of the Friedrich-Schiller-University of Jena. (KST 21007087). GPA is supported by a NHMRC Senior Research Fellowship 1080963.